Drug interactions
Amiodarone + Linagliptin-metformin
Severity: Minor
Amiodarone and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may inhibit renal cationic transport of metformin and raise its exposure. The clinical significance is uncertain and the data are limited.
What this interaction means in plain words
Amiodarone and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Linagliptin-metformin belongs to Endocrine.
Why it happens
Possible competition or inhibition at renal organic cation transporters (OCT2/MATE) reduces tubular secretion of metformin.
What to do
No routine dose change is needed; monitor glycemic control and renal function, and watch for gastrointestinal intolerance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Linagliptin-metformin?
MediHelp rates the interaction as minor. Amiodarone and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may inhibit renal cationic transport of metformin and raise its exposure. The clinical significance is uncertain and the data are limited.
How serious is the interaction between Amiodarone and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor glycemic control and renal function, and watch for gastrointestinal intolerance.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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