Drug interactions
Amiodarone + Naldemedine
Severity: Minor
Amiodarone and Naldemedine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits P-glycoprotein and CYP3A4 to some extent and may increase naldemedine exposure. This can increase opioid-withdrawal-like gastrointestinal effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Amiodarone and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Inhibition of P-glycoprotein efflux and weak CYP3A4 metabolism by amiodarone raises naldemedine concentrations.
What to do
No dose change is routinely required. Monitor for abdominal pain, diarrhea and signs of opioid withdrawal.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Amiodarone with Naldemedine?
MediHelp rates the interaction as minor. Amiodarone and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone inhibits P-glycoprotein and CYP3A4 to some extent and may increase naldemedine exposure. This can increase opioid-withdrawal-like gastrointestinal effects such as abdominal pain and diarrhea.
How serious is the interaction between Amiodarone and Naldemedine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required. Monitor for abdominal pain, diarrhea and signs of opioid withdrawal.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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