Drug interactions
Amiodarone + Naloxegol
Severity: Moderate
Amiodarone and Naloxegol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may increase naloxegol concentrations through CYP3A4 inhibition. This raises the chance of opioid withdrawal symptoms and gastrointestinal adverse effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Amiodarone and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Amiodarone inhibits CYP3A4, reducing naloxegol clearance.
What to do
If coadministered, reduce naloxegol to 12.5 mg daily and monitor for withdrawal and abdominal symptoms. Consider an alternative laxative if intolerant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Amiodarone with Naloxegol?
MediHelp rates the interaction as moderate. Amiodarone and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may increase naloxegol concentrations through CYP3A4 inhibition. This raises the chance of opioid withdrawal symptoms and gastrointestinal adverse effects such as abdominal pain and diarrhea.
How serious is the interaction between Amiodarone and Naloxegol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministered, reduce naloxegol to 12.5 mg daily and monitor for withdrawal and abdominal symptoms. Consider an alternative laxative if intolerant.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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