Drug interactions
Amiodarone + Oxymorphone
Severity: Minor
Amiodarone and Oxymorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxymorphone is metabolized mainly by glucuronidation rather than CYP2D6, so amiodarone's CYP2D6 inhibition is not expected to raise oxymorphone levels significantly. Any interaction is therefore likely to be small. Amiodarone may contribute to bradycardia and hypotension, which can add to opioid effects.
What this interaction means in plain words
Amiodarone and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Oxymorphone belongs to Musculoskeletal.
Why it happens
Amiodarone inhibits CYP2D6, but oxymorphone depends little on this pathway, so the pharmacokinetic effect is likely negligible.
What to do
No routine adjustment is required. Monitor for excess sedation and hypotension when starting or titrating either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Oxymorphone?
MediHelp rates the interaction as minor. Amiodarone and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxymorphone is metabolized mainly by glucuronidation rather than CYP2D6, so amiodarone's CYP2D6 inhibition is not expected to raise oxymorphone levels significantly. Any interaction is therefore likely to be small. Amiodarone may contribute to bradycardia and hypotension, which can add to opioid effects.
How serious is the interaction between Amiodarone and Oxymorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required. Monitor for excess sedation and hypotension when starting or titrating either drug.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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