Drug interactions
Amiodarone + Paclitaxel
Severity: Moderate
Amiodarone and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits P-glycoprotein and CYP3A4 and might increase paclitaxel exposure, with greater neutropenia and neuropathy. Clinical evidence is limited.
What this interaction means in plain words
Amiodarone and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Paclitaxel belongs to Oncology.
Why it happens
P-glycoprotein and CYP3A4 inhibition by amiodarone may reduce paclitaxel clearance and efflux.
What to do
Monitor blood counts and neuropathy symptoms during paclitaxel therapy. Reduce the paclitaxel dose if toxicity increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Paclitaxel
Frequently asked questions
Can I take Amiodarone with Paclitaxel?
MediHelp rates the interaction as moderate. Amiodarone and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits P-glycoprotein and CYP3A4 and might increase paclitaxel exposure, with greater neutropenia and neuropathy. Clinical evidence is limited.
How serious is the interaction between Amiodarone and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms during paclitaxel therapy. Reduce the paclitaxel dose if toxicity increases.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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