Drug interactions
Amiodarone + Prednisone
Severity: Moderate
Amiodarone and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can cause hypokalemia, which increases the risk of QT prolongation and torsades de pointes with amiodarone. Amiodarone may also modestly raise corticosteroid exposure through P-glycoprotein or CYP3A4 inhibition.
What this interaction means in plain words
Amiodarone and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Prednisone belongs to Endocrine.
Why it happens
Corticosteroid-induced hypokalemia adds to amiodarone QT effects, with possible minor pharmacokinetic inhibition by amiodarone.
What to do
Monitor serum potassium and magnesium and the ECG QT interval, and correct electrolyte disturbances promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Prednisone?
MediHelp rates the interaction as moderate. Amiodarone and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can cause hypokalemia, which increases the risk of QT prolongation and torsades de pointes with amiodarone. Amiodarone may also modestly raise corticosteroid exposure through P-glycoprotein or CYP3A4 inhibition.
How serious is the interaction between Amiodarone and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and the ECG QT interval, and correct electrolyte disturbances promptly.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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