Drug interactions
Amiodarone + Sarecycline
Severity: Minor
Amiodarone and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is a weak P-glycoprotein inhibitor, and amiodarone is a P-gp substrate, so exposure to amiodarone could rise slightly. The effect is expected to be small at usual doses.
What this interaction means in plain words
Amiodarone and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Sarecycline belongs to Anti Bacterial.
Why it happens
Weak P-glycoprotein inhibition by sarecycline may reduce amiodarone efflux.
What to do
No dose adjustment is usually needed. Monitor heart rate and ECG for signs of amiodarone excess.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Amiodarone with Sarecycline?
MediHelp rates the interaction as minor. Amiodarone and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is a weak P-glycoprotein inhibitor, and amiodarone is a P-gp substrate, so exposure to amiodarone could rise slightly. The effect is expected to be small at usual doses.
How serious is the interaction between Amiodarone and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor heart rate and ECG for signs of amiodarone excess.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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