Drug interactions
Amiodarone + Saxagliptin-metformin
Severity: Minor
Amiodarone and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may increase metformin exposure by reducing its renal elimination, although the clinical significance is uncertain. Higher levels could add to the risk of gastrointestinal effects and, rarely, lactic acidosis.
What this interaction means in plain words
Amiodarone and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Amiodarone may compete with metformin for renal tubular secretion via OCT2 and MATE transporters.
What to do
Monitor glycemic control and renal function, and reduce the metformin dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Amiodarone and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may increase metformin exposure by reducing its renal elimination, although the clinical significance is uncertain. Higher levels could add to the risk of gastrointestinal effects and, rarely, lactic acidosis.
How serious is the interaction between Amiodarone and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function, and reduce the metformin dose if adverse effects occur.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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