Drug interactions
Amiodarone + Sertraline
Severity: Moderate
Amiodarone and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, although sertraline has a relatively low liability. Combined use may raise the risk of torsades de pointes, especially with electrolyte disturbances or other risk factors.
What this interaction means in plain words
Amiodarone and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QTc prolongation.
What to do
Obtain a baseline and follow-up ECG and keep potassium and magnesium normal. Consider a lower-risk antidepressant if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Amiodarone with Sertraline?
MediHelp rates the interaction as moderate. Amiodarone and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, although sertraline has a relatively low liability. Combined use may raise the risk of torsades de pointes, especially with electrolyte disturbances or other risk factors.
How serious is the interaction between Amiodarone and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline and follow-up ECG and keep potassium and magnesium normal. Consider a lower-risk antidepressant if QTc becomes prolonged.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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