Drug interactions
Amiodarone + Sparsentan
Severity: Moderate
Amiodarone and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may raise sparsentan exposure through CYP3A4 inhibition, which could increase hypotension, edema, hyperkalemia and renal effects. Sparsentan, a weak CYP2C19 inducer, could in theory lower exposure to CYP2C19-metabolized drugs, though this is of uncertain relevance for amiodarone.
What this interaction means in plain words
Amiodarone and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
Why it happens
Amiodarone inhibits CYP3A4, which metabolizes sparsentan; sparsentan induces CYP2C19.
What to do
No sparsentan dose change is generally required, but monitor blood pressure, serum potassium, edema and renal function. Also watch for loss of amiodarone effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Amiodarone with Sparsentan?
MediHelp rates the interaction as moderate. Amiodarone and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may raise sparsentan exposure through CYP3A4 inhibition, which could increase hypotension, edema, hyperkalemia and renal effects. Sparsentan, a weak CYP2C19 inducer, could in theory lower exposure to CYP2C19-metabolized drugs, though this is of uncertain relevance for amiodarone.
How serious is the interaction between Amiodarone and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No sparsentan dose change is generally required, but monitor blood pressure, serum potassium, edema and renal function. Also watch for loss of amiodarone effect.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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