Drug interactions
Amiodarone + Tamsulosin
Severity: Moderate
Amiodarone and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP3A4 and CYP2D6, both involved in tamsulosin clearance, and may raise tamsulosin levels. This may increase hypotension and dizziness.
What this interaction means in plain words
Amiodarone and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Tamsulosin belongs to Genitourinary.
Why it happens
Inhibition of CYP2D6 and CYP3A4 metabolism of tamsulosin by amiodarone.
What to do
Monitor blood pressure and orthostatic symptoms, particularly during the first weeks of combined therapy. Lower the tamsulosin dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Tamsulosin?
MediHelp rates the interaction as moderate. Amiodarone and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP3A4 and CYP2D6, both involved in tamsulosin clearance, and may raise tamsulosin levels. This may increase hypotension and dizziness.
How serious is the interaction between Amiodarone and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly during the first weeks of combined therapy. Lower the tamsulosin dose if symptomatic hypotension occurs.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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