Drug interactions
Amiodarone + Terbinafine
Severity: Moderate
Amiodarone and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbinafine inhibits CYP2D6 and may modestly affect other metabolic pathways. Amiodarone has a very long half-life and both drugs are associated with hepatotoxicity and, rarely, QT effects. Documented pharmacokinetic interaction is limited, and the legacy mechanism via CYP2C9 raising terbinafine is poorly supported.
What this interaction means in plain words
Amiodarone and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Terbinafine belongs to Anti Fungals.
Why it happens
Possible inhibition of terbinafine clearance by amiodarone and additive hepatotoxicity; the mechanism is not firmly established.
What to do
Monitor liver function tests and ECG during combined use. Consider an alternative antifungal if hepatic or cardiac abnormalities appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Terbinafine?
MediHelp rates the interaction as moderate. Amiodarone and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbinafine inhibits CYP2D6 and may modestly affect other metabolic pathways. Amiodarone has a very long half-life and both drugs are associated with hepatotoxicity and, rarely, QT effects. Documented pharmacokinetic interaction is limited, and the legacy mechanism via CYP2C9 raising terbinafine is poorly supported.
How serious is the interaction between Amiodarone and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and ECG during combined use. Consider an alternative antifungal if hepatic or cardiac abnormalities appear.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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