Drug interactions
Amiodarone + Tolbutamide
Severity: Minor
Amiodarone and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone can inhibit CYP2C9, which clears tolbutamide, potentially raising tolbutamide levels. This may enhance the glucose-lowering effect and increase the risk of hypoglycemia.
What this interaction means in plain words
Amiodarone and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Tolbutamide belongs to Endocrine.
Why it happens
Amiodarone inhibits CYP2C9-mediated metabolism of tolbutamide.
What to do
Monitor blood glucose when starting or stopping amiodarone. Reduce the tolbutamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Amiodarone with Tolbutamide?
MediHelp rates the interaction as minor. Amiodarone and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone can inhibit CYP2C9, which clears tolbutamide, potentially raising tolbutamide levels. This may enhance the glucose-lowering effect and increase the risk of hypoglycemia.
How serious is the interaction between Amiodarone and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping amiodarone. Reduce the tolbutamide dose if hypoglycemia occurs.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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