Drug interactions
Amiodarone + Vinblastine
Severity: Moderate
Amiodarone and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may increase vinblastine exposure and its toxicity, including neutropenia and neurotoxicity. The interaction is largely predicted from the mechanism.
What this interaction means in plain words
Amiodarone and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Vinblastine belongs to Oncology.
Why it happens
Amiodarone inhibits P-glycoprotein and CYP3A4, decreasing vinblastine efflux and metabolism.
What to do
Monitor blood counts and for neuropathy or gastrointestinal toxicity, and reduce the vinblastine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Vinblastine
Frequently asked questions
Can I take Amiodarone with Vinblastine?
MediHelp rates the interaction as moderate. Amiodarone and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may increase vinblastine exposure and its toxicity, including neutropenia and neurotoxicity. The interaction is largely predicted from the mechanism.
How serious is the interaction between Amiodarone and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for neuropathy or gastrointestinal toxicity, and reduce the vinblastine dose if toxicity appears.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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