Drug interactions
Amiodarone + Zafirlukast
Severity: Minor
Amiodarone and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone is metabolized in part by CYP3A4, and zafirlukast may weakly inhibit this enzyme. Amiodarone levels could rise modestly, which matters given its narrow therapeutic index and QT-prolonging and organ toxicity potential.
What this interaction means in plain words
Amiodarone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Zafirlukast belongs to Respiratory.
Why it happens
Zafirlukast weakly inhibits CYP3A4, potentially reducing amiodarone metabolism.
What to do
Monitor heart rate and ECG, including QTc, when starting or stopping zafirlukast in a patient taking amiodarone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Zafirlukast?
MediHelp rates the interaction as minor. Amiodarone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone is metabolized in part by CYP3A4, and zafirlukast may weakly inhibit this enzyme. Amiodarone levels could rise modestly, which matters given its narrow therapeutic index and QT-prolonging and organ toxicity potential.
How serious is the interaction between Amiodarone and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, including QTc, when starting or stopping zafirlukast in a patient taking amiodarone.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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