Drug interactions
Amisulpride + Disopyramide
Severity: Contraindicated
Amisulpride and Disopyramide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is a class Ia antiarrhythmic that prolongs the QT interval and has caused torsades de pointes. Amisulpride adds further QT prolongation, so the combination markedly increases proarrhythmic risk.
What this interaction means in plain words
Amisulpride and Disopyramide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amisulpride belongs to Central Nervous System; Disopyramide belongs to Cardiovascular.
Why it happens
Additive QT prolongation through potassium channel blockade.
What to do
Avoid the combination and select an antipsychotic or antiarrhythmic with lower QT risk. If unavoidable, monitor the ECG closely and correct potassium and magnesium.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Amisulpride + Pimozide Contraindicated
Other interactions of Disopyramide
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Amisulpride with Disopyramide?
MediHelp rates the interaction as contraindicated. Amisulpride and Disopyramide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Disopyramide is a class Ia antiarrhythmic that prolongs the QT interval and has caused torsades de pointes. Amisulpride adds further QT prolongation, so the combination markedly increases proarrhythmic risk.
How serious is the interaction between Amisulpride and Disopyramide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select an antipsychotic or antiarrhythmic with lower QT risk. If unavoidable, monitor the ECG closely and correct potassium and magnesium.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Dofetilide. The full list is on the Amisulpride page.
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