Drug interactions
Amitriptyline + Avapritinib
Severity: Moderate
Amitriptyline and Avapritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, and amitriptyline is itself sedating. Used together, they may worsen drowsiness, confusion, and impaired concentration.
What this interaction means in plain words
Amitriptyline and Avapritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Avapritinib belongs to Oncology.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and cognitive changes, and advise patients to avoid driving or hazardous tasks if affected. Reduce the amitriptyline dose or consider an alternative if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Amitriptyline with Avapritinib?
MediHelp rates the interaction as moderate. Amitriptyline and Avapritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, and amitriptyline is itself sedating. Used together, they may worsen drowsiness, confusion, and impaired concentration.
How serious is the interaction between Amitriptyline and Avapritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes, and advise patients to avoid driving or hazardous tasks if affected. Reduce the amitriptyline dose or consider an alternative if symptoms develop.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
Full monographs, dosing and an interaction checker in the MediHelp app
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