Drug interactions
Amitriptyline + Bortezomib
Severity: Minor
Amitriptyline and Bortezomib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib is a weak inhibitor of CYP2C19 in vitro, which could slightly raise amitriptyline levels. Clinically relevant changes are not established, though both can cause neuropathy-related or orthostatic effects.
What this interaction means in plain words
Amitriptyline and Bortezomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Bortezomib belongs to Oncology.
Why it happens
Possible weak inhibition of CYP2C19-mediated amitriptyline demethylation.
What to do
No routine adjustment is needed. Monitor for anticholinergic or sedative effects and adjust the amitriptyline dose if they emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Amitriptyline with Bortezomib?
MediHelp rates the interaction as minor. Amitriptyline and Bortezomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bortezomib is a weak inhibitor of CYP2C19 in vitro, which could slightly raise amitriptyline levels. Clinically relevant changes are not established, though both can cause neuropathy-related or orthostatic effects.
How serious is the interaction between Amitriptyline and Bortezomib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for anticholinergic or sedative effects and adjust the amitriptyline dose if they emerge.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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