Drug interactions
Amitriptyline + Bosentan
Severity: Minor
Amitriptyline and Bosentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and CYP2C9 and could modestly lower amitriptyline concentrations. A clinically significant loss of antidepressant effect is not well documented.
What this interaction means in plain words
Amitriptyline and Bosentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Bosentan belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 by bosentan, increasing amitriptyline metabolism.
What to do
Monitor antidepressant response and consider a dose increase if efficacy declines after bosentan is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amitriptyline and Bosentan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Frequently asked questions
Can I take Amitriptyline with Bosentan?
MediHelp rates the interaction as minor. Amitriptyline and Bosentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan induces CYP3A4 and CYP2C9 and could modestly lower amitriptyline concentrations. A clinically significant loss of antidepressant effect is not well documented.
How serious is the interaction between Amitriptyline and Bosentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and consider a dose increase if efficacy declines after bosentan is started.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
