Drug interactions
Baclofen + Cinnarizine
Severity: Moderate
Baclofen and Cinnarizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine is a sedating antihistamine and calcium channel blocker that can cause drowsiness. With baclofen, sedation and impaired alertness may increase.
What this interaction means in plain words
Baclofen and Cinnarizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Cinnarizine belongs to Respiratory.
Why it happens
Additive CNS depression from H1-antihistamine activity and baclofen's GABA-B agonism.
What to do
Counsel patients about drowsiness and driving, and monitor older patients for falls. Reduce doses if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Baclofen with Cinnarizine?
MediHelp rates the interaction as moderate. Baclofen and Cinnarizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine is a sedating antihistamine and calcium channel blocker that can cause drowsiness. With baclofen, sedation and impaired alertness may increase.
How serious is the interaction between Baclofen and Cinnarizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and driving, and monitor older patients for falls. Reduce doses if sedation is excessive.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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