Drug interactions
Amitriptyline + Clobazam
Severity: Moderate
Amitriptyline and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam and its metabolite are weak CYP2D6 inhibitors and may modestly raise amitriptyline exposure. Both are CNS depressants, so sedation and psychomotor impairment may be additive.
What this interaction means in plain words
Amitriptyline and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Clobazam belongs to Central Nervous System.
Why it happens
Weak CYP2D6 inhibition by clobazam plus additive CNS depression.
What to do
Monitor for sedation and tricyclic adverse effects, and consider a lower amitriptyline dose. Counsel patients about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Amitriptyline with Clobazam?
MediHelp rates the interaction as moderate. Amitriptyline and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam and its metabolite are weak CYP2D6 inhibitors and may modestly raise amitriptyline exposure. Both are CNS depressants, so sedation and psychomotor impairment may be additive.
How serious is the interaction between Amitriptyline and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and tricyclic adverse effects, and consider a lower amitriptyline dose. Counsel patients about driving and alcohol.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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