Drug interactions
Amitriptyline + Clorazepate
Severity: Moderate
Amitriptyline and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining these drugs can produce greater sedation, dizziness and impaired psychomotor performance than either alone. The risk is higher in older adults and with higher doses, and falls or accidents may result.
What this interaction means in plain words
Amitriptyline and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Clorazepate belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and the antihistaminic and anticholinergic effects of amitriptyline.
What to do
Use the lowest effective doses and monitor for oversedation and confusion, particularly in older patients. Counsel about driving and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Clorazepate?
MediHelp rates the interaction as moderate. Amitriptyline and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining these drugs can produce greater sedation, dizziness and impaired psychomotor performance than either alone. The risk is higher in older adults and with higher doses, and falls or accidents may result.
How serious is the interaction between Amitriptyline and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and confusion, particularly in older patients. Counsel about driving and avoid alcohol.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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