Drug interactions
Amitriptyline + Crizotinib
Severity: Major
Amitriptyline and Crizotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and crizotinib can also cause bradycardia. Together they increase the risk of torsades de pointes, especially with electrolyte abnormalities.
What this interaction means in plain words
Amitriptyline and Crizotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Crizotinib belongs to Oncology.
Why it happens
Additive blockade of cardiac repolarising potassium channels, with crizotinib-related bradycardia.
What to do
Avoid if possible, or monitor ECG and electrolytes closely. Correct potassium and magnesium and reduce or stop crizotinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Amitriptyline with Crizotinib?
MediHelp rates the interaction as major. Amitriptyline and Crizotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and crizotinib can also cause bradycardia. Together they increase the risk of torsades de pointes, especially with electrolyte abnormalities.
How serious is the interaction between Amitriptyline and Crizotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or monitor ECG and electrolytes closely. Correct potassium and magnesium and reduce or stop crizotinib if QTc becomes markedly prolonged.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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