Drug interactions
Amitriptyline + Darunavir
Severity: Moderate
Amitriptyline and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with a booster such as ritonavir or cobicistat, can increase amitriptyline concentrations. This raises the risk of sedation, anticholinergic effects, and QT or conduction abnormalities.
What this interaction means in plain words
Amitriptyline and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Darunavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 (and booster-related CYP2D6 inhibition) reducing amitriptyline metabolism.
What to do
Use the lowest feasible amitriptyline starting dose and titrate carefully to response. Monitor for toxicity and consider ECG monitoring in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Amitriptyline with Darunavir?
MediHelp rates the interaction as moderate. Amitriptyline and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually given with a booster such as ritonavir or cobicistat, can increase amitriptyline concentrations. This raises the risk of sedation, anticholinergic effects, and QT or conduction abnormalities.
How serious is the interaction between Amitriptyline and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest feasible amitriptyline starting dose and titrate carefully to response. Monitor for toxicity and consider ECG monitoring in high-risk patients.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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