Drug interactions
Baclofen + Difelikefalin
Severity: Moderate
Baclofen and Difelikefalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause dizziness, somnolence and mental status changes, and baclofen may add to these effects. This matters especially in dialysis patients, who also clear baclofen poorly.
What this interaction means in plain words
Baclofen and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS depression; difelikefalin is a peripherally restricted kappa-opioid agonist with some CNS effects.
What to do
Monitor for somnolence, dizziness and confusion, and keep baclofen doses low in renal impairment. Advise patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Baclofen with Difelikefalin?
MediHelp rates the interaction as moderate. Baclofen and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin can cause dizziness, somnolence and mental status changes, and baclofen may add to these effects. This matters especially in dialysis patients, who also clear baclofen poorly.
How serious is the interaction between Baclofen and Difelikefalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for somnolence, dizziness and confusion, and keep baclofen doses low in renal impairment. Advise patients to avoid driving until the response is known.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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