Drug interactions
Amitriptyline + Eslicarbazepine
Severity: Moderate
Amitriptyline and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine can inhibit CYP2C19, which contributes to amitriptyline demethylation to nortriptyline, so amitriptyline exposure may rise modestly. This may increase anticholinergic, sedative and cardiac adverse effects.
What this interaction means in plain words
Amitriptyline and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19-mediated amitriptyline metabolism by eslicarbazepine; enzyme induction at other pathways may also occur.
What to do
Monitor for tricyclic toxicity and clinical response after starting or stopping eslicarbazepine. Consider checking tricyclic plasma levels and adjusting the amitriptyline dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Amitriptyline with Eslicarbazepine?
MediHelp rates the interaction as moderate. Amitriptyline and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine can inhibit CYP2C19, which contributes to amitriptyline demethylation to nortriptyline, so amitriptyline exposure may rise modestly. This may increase anticholinergic, sedative and cardiac adverse effects.
How serious is the interaction between Amitriptyline and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity and clinical response after starting or stopping eslicarbazepine. Consider checking tricyclic plasma levels and adjusting the amitriptyline dose.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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