Drug interactions
Amitriptyline + Etravirine
Severity: Moderate
Amitriptyline and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine inhibits CYP2C19, one of the enzymes that demethylate amitriptyline, and may modestly increase its levels. Tricyclic adverse effects such as sedation and anticholinergic symptoms could become more prominent.
What this interaction means in plain words
Amitriptyline and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Etravirine belongs to Anti Virals.
Why it happens
Etravirine inhibition of CYP2C19 reduces amitriptyline metabolism.
What to do
Monitor for tricyclic toxicity and clinical response, and lower the amitriptyline dose if adverse effects emerge. Consider an ECG in patients at cardiac risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Amitriptyline with Etravirine?
MediHelp rates the interaction as moderate. Amitriptyline and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine inhibits CYP2C19, one of the enzymes that demethylate amitriptyline, and may modestly increase its levels. Tricyclic adverse effects such as sedation and anticholinergic symptoms could become more prominent.
How serious is the interaction between Amitriptyline and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity and clinical response, and lower the amitriptyline dose if adverse effects emerge. Consider an ECG in patients at cardiac risk.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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