Drug interactions
Amitriptyline + Fosaprepitant
Severity: Minor
Amitriptyline and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant, the active form of fosaprepitant, is a moderate CYP3A4 inhibitor that may slightly raise amitriptyline levels. A single-dose regimen is unlikely to cause a clinically significant effect.
What this interaction means in plain words
Amitriptyline and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Temporary CYP3A4 inhibition by aprepitant slows a minor metabolic pathway of amitriptyline.
What to do
No dose adjustment is usually needed; watch for increased sedation or anticholinergic effects during chemotherapy cycles.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Amitriptyline with Fosaprepitant?
MediHelp rates the interaction as minor. Amitriptyline and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant, the active form of fosaprepitant, is a moderate CYP3A4 inhibitor that may slightly raise amitriptyline levels. A single-dose regimen is unlikely to cause a clinically significant effect.
How serious is the interaction between Amitriptyline and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; watch for increased sedation or anticholinergic effects during chemotherapy cycles.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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