Drug interactions
Amitriptyline + Indacaterol-glycopyrronium
Severity: Moderate
Amitriptyline and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may potentiate the cardiovascular effects of long-acting beta-2 agonists and prolong QTc, and amitriptyline also adds anticholinergic burden to glycopyrronium. This may cause arrhythmias, tachycardia, dry mouth and urinary retention.
What this interaction means in plain words
Amitriptyline and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive QT prolongation, enhanced adrenergic cardiovascular effects and additive antimuscarinic activity.
What to do
Monitor ECG and heart rate and watch for anticholinergic effects; consider a less anticholinergic antidepressant if problems occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amitriptyline and Indacaterol-glycopyrronium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Indacaterol-glycopyrronium
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Amitriptyline and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants may potentiate the cardiovascular effects of long-acting beta-2 agonists and prolong QTc, and amitriptyline also adds anticholinergic burden to glycopyrronium. This may cause arrhythmias, tachycardia, dry mouth and urinary retention.
How serious is the interaction between Amitriptyline and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate and watch for anticholinergic effects; consider a less anticholinergic antidepressant if problems occur.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
