Drug interactions
Amitriptyline + Indacaterol
Severity: Major
Amitriptyline and Indacaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can prolong QT and potentiate the cardiovascular effects of beta-2 agonists. The combination may increase the risk of palpitations, tachycardia and ventricular arrhythmias.
What this interaction means in plain words
Amitriptyline and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Indacaterol belongs to Respiratory.
Why it happens
Additive QT prolongation and potentiation of adrenergic cardiovascular effects, with tricyclic inhibition of catecholamine reuptake.
What to do
Use only if needed and monitor ECG and heart rate, correcting potassium and magnesium. Consider alternative therapy in patients with cardiac disease or prolonged QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Indacaterol?
MediHelp rates the interaction as major. Amitriptyline and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can prolong QT and potentiate the cardiovascular effects of beta-2 agonists. The combination may increase the risk of palpitations, tachycardia and ventricular arrhythmias.
How serious is the interaction between Amitriptyline and Indacaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if needed and monitor ECG and heart rate, correcting potassium and magnesium. Consider alternative therapy in patients with cardiac disease or prolonged QTc.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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