Drug interactions
Arsenic trioxide + Indacaterol
Severity: Major
Arsenic trioxide and Indacaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arsenic trioxide causes marked QT prolongation and torsades de pointes, and its labeling advises caution with other QT-prolonging drugs. Indacaterol can add to QT effects and may lower potassium. This increases the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Arsenic trioxide and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Indacaterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with possible beta-agonist-induced hypokalemia.
What to do
Avoid the combination if a suitable alternative exists; otherwise monitor ECG and keep potassium and magnesium corrected throughout arsenic trioxide therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Arsenic trioxide + Clomipramine Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Arsenic trioxide + Fluphenazine Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
Frequently asked questions
Can I take Arsenic trioxide with Indacaterol?
MediHelp rates the interaction as major. Arsenic trioxide and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide causes marked QT prolongation and torsades de pointes, and its labeling advises caution with other QT-prolonging drugs. Indacaterol can add to QT effects and may lower potassium. This increases the risk of serious ventricular arrhythmia.
How serious is the interaction between Arsenic trioxide and Indacaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if a suitable alternative exists; otherwise monitor ECG and keep potassium and magnesium corrected throughout arsenic trioxide therapy.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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