Drug interactions
Amiodarone + Indacaterol
Severity: Major
Amiodarone and Indacaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone markedly prolongs the QT interval and carries a known risk of torsades de pointes. Adding a beta-2 agonist that can cause tachycardia and hypokalemia may further raise arrhythmic risk.
What this interaction means in plain words
Amiodarone and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Indacaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta-agonist induced hypokalemia and sympathetic stimulation.
What to do
Obtain baseline and follow-up ECGs and maintain normal potassium and magnesium. Consider an alternative bronchodilator in patients with a long QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Indacaterol?
MediHelp rates the interaction as major. Amiodarone and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone markedly prolongs the QT interval and carries a known risk of torsades de pointes. Adding a beta-2 agonist that can cause tachycardia and hypokalemia may further raise arrhythmic risk.
How serious is the interaction between Amiodarone and Indacaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and follow-up ECGs and maintain normal potassium and magnesium. Consider an alternative bronchodilator in patients with a long QTc.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amisulpride, Amitriptyline. The full list is on the Indacaterol page.
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