Drug interactions
Amitriptyline + Ipratropium
Severity: Minor
Amitriptyline and Ipratropium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline has strong anticholinergic activity and may add to the effects of ipratropium. Inhaled ipratropium is poorly absorbed, so clinically significant systemic effects are unlikely at usual doses.
What this interaction means in plain words
Amitriptyline and Ipratropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Ipratropium belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic symptoms such as dry mouth, urinary retention and constipation. Take extra care in older adults or those with glaucoma or prostatic hypertrophy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Ipratropium?
MediHelp rates the interaction as minor. Amitriptyline and Ipratropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amitriptyline has strong anticholinergic activity and may add to the effects of ipratropium. Inhaled ipratropium is poorly absorbed, so clinically significant systemic effects are unlikely at usual doses.
How serious is the interaction between Amitriptyline and Ipratropium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms such as dry mouth, urinary retention and constipation. Take extra care in older adults or those with glaucoma or prostatic hypertrophy.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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