Drug interactions
Amitriptyline + Ivacaftor
Severity: Minor
Amitriptyline and Ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor weakly inhibits P-glycoprotein and CYP3A, which could slightly raise amitriptyline levels. The clinical effect is expected to be small, but tricyclic toxicity is possible in susceptible patients.
What this interaction means in plain words
Amitriptyline and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Ivacaftor belongs to Miscellaneous.
Why it happens
Weak inhibition of P-glycoprotein and CYP3A by ivacaftor.
What to do
No empirical dose change is needed; monitor for anticholinergic effects, sedation and cardiac symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Amitriptyline with Ivacaftor?
MediHelp rates the interaction as minor. Amitriptyline and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor weakly inhibits P-glycoprotein and CYP3A, which could slightly raise amitriptyline levels. The clinical effect is expected to be small, but tricyclic toxicity is possible in susceptible patients.
How serious is the interaction between Amitriptyline and Ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for anticholinergic effects, sedation and cardiac symptoms.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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