Drug interactions
Amitriptyline + Lasmiditan
Severity: Minor
Amitriptyline and Lasmiditan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and could raise exposure to P-gp substrates, but amitriptyline is not a clinically significant P-gp substrate. Additive CNS effects such as dizziness and sedation are more plausible.
What this interaction means in plain words
Amitriptyline and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Theoretical P-gp inhibition; additive CNS depression is more likely than a pharmacokinetic effect.
What to do
No dose change is needed routinely. Counsel patients about additive drowsiness and avoid driving for at least 8 hours after lasmiditan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Amitriptyline with Lasmiditan?
MediHelp rates the interaction as minor. Amitriptyline and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits P-glycoprotein in vitro and could raise exposure to P-gp substrates, but amitriptyline is not a clinically significant P-gp substrate. Additive CNS effects such as dizziness and sedation are more plausible.
How serious is the interaction between Amitriptyline and Lasmiditan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed routinely. Counsel patients about additive drowsiness and avoid driving for at least 8 hours after lasmiditan.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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