Drug interactions
Amitriptyline + Lurasidone
Severity: Moderate
Amitriptyline and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and orthostatic hypotension, so combined use may increase dizziness, falls and impaired alertness. Amitriptyline may also add to cardiac effects of the antipsychotic.
What this interaction means in plain words
Amitriptyline and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive alpha-1 adrenergic and histamine H1 blockade leading to sedation and hypotension.
What to do
Monitor blood pressure and sedation, especially during dose changes, and advise slow postural changes. Reduce doses if orthostatic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Amitriptyline with Lurasidone?
MediHelp rates the interaction as moderate. Amitriptyline and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and orthostatic hypotension, so combined use may increase dizziness, falls and impaired alertness. Amitriptyline may also add to cardiac effects of the antipsychotic.
How serious is the interaction between Amitriptyline and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation, especially during dose changes, and advise slow postural changes. Reduce doses if orthostatic symptoms occur.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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