Drug interactions
Amitriptyline + Nabilone
Severity: Moderate
Amitriptyline and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and each can increase heart rate, so together they may cause excessive drowsiness, tachycardia, and confusion. Cannabinoids combined with tricyclics can also cause additive anticholinergic effects and orthostatic hypotension.
What this interaction means in plain words
Amitriptyline and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression and sympathomimetic or anticholinergic effects on heart rate.
What to do
Monitor heart rate, blood pressure and level of sedation, and start with low doses. Counsel patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Nabilone?
MediHelp rates the interaction as moderate. Amitriptyline and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and each can increase heart rate, so together they may cause excessive drowsiness, tachycardia, and confusion. Cannabinoids combined with tricyclics can also cause additive anticholinergic effects and orthostatic hypotension.
How serious is the interaction between Amitriptyline and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and level of sedation, and start with low doses. Counsel patients to avoid driving until the response is known.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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