Drug interactions
Amitriptyline + Osilodrostat
Severity: Moderate
Amitriptyline and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia, or underlying heart disease.
What this interaction means in plain words
Amitriptyline and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Osilodrostat belongs to Endocrine.
Why it happens
Additive QTc prolongation.
What to do
Obtain a baseline ECG and repeat it after dose changes, and keep potassium and magnesium within normal range. Consider an alternative if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Amitriptyline with Osilodrostat?
MediHelp rates the interaction as moderate. Amitriptyline and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia, or underlying heart disease.
How serious is the interaction between Amitriptyline and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it after dose changes, and keep potassium and magnesium within normal range. Consider an alternative if QTc becomes markedly prolonged.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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