Drug interactions
Amitriptyline + Osimertinib
Severity: Moderate
Amitriptyline and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib and amitriptyline can each lengthen the QT interval, so combining them may increase the risk of serious ventricular arrhythmia. Patients with electrolyte abnormalities or cardiac disease are at greater risk.
What this interaction means in plain words
Amitriptyline and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Osimertinib belongs to Oncology.
Why it happens
Additive QTc prolongation.
What to do
Perform periodic ECG and electrolyte monitoring and correct abnormalities. Interrupt osimertinib or change the antidepressant if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Amitriptyline with Osimertinib?
MediHelp rates the interaction as moderate. Amitriptyline and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib and amitriptyline can each lengthen the QT interval, so combining them may increase the risk of serious ventricular arrhythmia. Patients with electrolyte abnormalities or cardiac disease are at greater risk.
How serious is the interaction between Amitriptyline and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG and electrolyte monitoring and correct abnormalities. Interrupt osimertinib or change the antidepressant if QTc becomes markedly prolonged.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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