Drug interactions
Amitriptyline + Oxaliplatin
Severity: Moderate
Amitriptyline and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been associated with QT prolongation and amitriptyline can also lengthen the QT interval. Electrolyte disturbances from chemotherapy such as vomiting or diarrhea may further raise arrhythmia risk.
What this interaction means in plain words
Amitriptyline and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Oxaliplatin belongs to Oncology.
Why it happens
Additive QT interval prolongation; oxaliplatin does not meaningfully alter amitriptyline levels.
What to do
Obtain a baseline ECG and monitor ECG and electrolytes during treatment, replacing potassium and magnesium as needed. Consider an alternative to amitriptyline for neuropathy if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Amitriptyline with Oxaliplatin?
MediHelp rates the interaction as moderate. Amitriptyline and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin has been associated with QT prolongation and amitriptyline can also lengthen the QT interval. Electrolyte disturbances from chemotherapy such as vomiting or diarrhea may further raise arrhythmia risk.
How serious is the interaction between Amitriptyline and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG and electrolytes during treatment, replacing potassium and magnesium as needed. Consider an alternative to amitriptyline for neuropathy if other QT risk factors are present.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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