Drug interactions
Amitriptyline + Peginterferon alfa 2b
Severity: Minor
Amitriptyline and Peginterferon alfa 2b: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa 2b may alter the activity of drug-metabolizing enzymes, but its effect on amitriptyline is unpredictable and has not been shown to be clinically important. Amitriptyline levels could change slightly. Depression is also a recognized interferon adverse effect, so the combination may be used together in practice.
What this interaction means in plain words
Amitriptyline and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Possible modest modulation of CYP2D6 activity by interferon; not firmly established.
What to do
Monitor depressive symptoms and tricyclic adverse effects such as anticholinergic effects and sedation. Adjust the dose according to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Peginterferon alfa 2b
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Peginterferon alfa 2b?
MediHelp rates the interaction as minor. Amitriptyline and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa 2b may alter the activity of drug-metabolizing enzymes, but its effect on amitriptyline is unpredictable and has not been shown to be clinically important. Amitriptyline levels could change slightly. Depression is also a recognized interferon adverse effect, so the combination may be used together in practice.
How serious is the interaction between Amitriptyline and Peginterferon alfa 2b?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor depressive symptoms and tricyclic adverse effects such as anticholinergic effects and sedation. Adjust the dose according to response.
What other medicines interact with Peginterferon alfa 2b?
MediHelp also lists interactions of Peginterferon alfa 2b with, for example, Aldesleukin, Deferiprone, Pexidartinib. The full list is on the Peginterferon alfa 2b page.
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