Drug interactions
Baclofen + Selinexor
Severity: Moderate
Baclofen and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and fatigue, and baclofen has similar CNS effects. Combined use may worsen neurological toxicity and increase the risk of falls.
What this interaction means in plain words
Baclofen and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Selinexor belongs to Oncology.
Why it happens
Additive neurological adverse effects; no pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and sedation, and counsel on fall precautions. Reduce the baclofen dose or review selinexor dosing if neurological symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Baclofen with Selinexor?
MediHelp rates the interaction as moderate. Baclofen and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and fatigue, and baclofen has similar CNS effects. Combined use may worsen neurological toxicity and increase the risk of falls.
How serious is the interaction between Baclofen and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation, and counsel on fall precautions. Reduce the baclofen dose or review selinexor dosing if neurological symptoms emerge.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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