Drug interactions
Amitriptyline + Sirolimus
Severity: Minor
Amitriptyline and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No well-established clinically significant interaction exists between these drugs. The suggested P-glycoprotein effect is theoretical and unlikely to change amitriptyline exposure meaningfully.
What this interaction means in plain words
Amitriptyline and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Sirolimus belongs to Miscellaneous.
Why it happens
Theoretical P-glycoprotein interaction that is not clinically established.
What to do
No specific action is needed beyond routine monitoring of tricyclic adverse effects and sirolimus trough concentrations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Amitriptyline with Sirolimus?
MediHelp rates the interaction as minor. Amitriptyline and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No well-established clinically significant interaction exists between these drugs. The suggested P-glycoprotein effect is theoretical and unlikely to change amitriptyline exposure meaningfully.
How serious is the interaction between Amitriptyline and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring of tricyclic adverse effects and sirolimus trough concentrations.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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