Drug interactions
Amitriptyline + Solifenacin
Severity: Moderate
Amitriptyline and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amitriptyline is strongly anticholinergic and combined with solifenacin it increases the risk of urinary retention, constipation, dry mouth, blurred vision, and delirium. Both drugs can also lengthen the QT interval, adding to arrhythmia risk.
What this interaction means in plain words
Amitriptyline and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects and additive QT prolongation.
What to do
Monitor for anticholinergic toxicity and cognitive effects, particularly in older adults. Consider an ECG in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Solifenacin?
MediHelp rates the interaction as moderate. Amitriptyline and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline is strongly anticholinergic and combined with solifenacin it increases the risk of urinary retention, constipation, dry mouth, blurred vision, and delirium. Both drugs can also lengthen the QT interval, adding to arrhythmia risk.
How serious is the interaction between Amitriptyline and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and cognitive effects, particularly in older adults. Consider an ECG in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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