Drug interactions
Amitriptyline + Temazepam
Severity: Moderate
Amitriptyline and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so combining them increases sedation, psychomotor impairment, and fall risk. Effects are more pronounced in older adults.
What this interaction means in plain words
Amitriptyline and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and antihistaminic and anticholinergic effects of amitriptyline.
What to do
Use the lowest effective doses and counsel patients about driving, alcohol, and fall risk. Avoid the combination in frail older adults where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Amitriptyline with Temazepam?
MediHelp rates the interaction as moderate. Amitriptyline and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so combining them increases sedation, psychomotor impairment, and fall risk. Effects are more pronounced in older adults.
How serious is the interaction between Amitriptyline and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients about driving, alcohol, and fall risk. Avoid the combination in frail older adults where possible.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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