Drug interactions
Amlodipine + Atazanavir
Severity: Moderate
Amlodipine and Atazanavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and can raise amlodipine concentrations, increasing the chance of hypotension and edema. It may also affect cardiac conduction, which matters in patients on other agents that slow the heart.
What this interaction means in plain words
Amlodipine and Atazanavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Atazanavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism by atazanavir.
What to do
Start with a lower amlodipine dose and monitor blood pressure and edema, titrating as needed. Consider an ECG if other conduction-affecting drugs are also being used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Amlodipine with Atazanavir?
MediHelp rates the interaction as moderate. Amlodipine and Atazanavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir inhibits CYP3A4 and can raise amlodipine concentrations, increasing the chance of hypotension and edema. It may also affect cardiac conduction, which matters in patients on other agents that slow the heart.
How serious is the interaction between Amlodipine and Atazanavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower amlodipine dose and monitor blood pressure and edema, titrating as needed. Consider an ECG if other conduction-affecting drugs are also being used.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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