Drug interactions
Amlodipine + Bosentan
Severity: Minor
Amlodipine and Bosentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and may reduce amlodipine concentrations, potentially weakening blood pressure or angina control. Bosentan itself can lower blood pressure, so the net effect is variable.
What this interaction means in plain words
Amlodipine and Bosentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Bosentan belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 by bosentan increases amlodipine metabolism.
What to do
Monitor blood pressure and symptoms when bosentan is started or stopped. Adjust the amlodipine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Amlodipine with Bosentan?
MediHelp rates the interaction as minor. Amlodipine and Bosentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a moderate CYP3A4 inducer and may reduce amlodipine concentrations, potentially weakening blood pressure or angina control. Bosentan itself can lower blood pressure, so the net effect is variable.
How serious is the interaction between Amlodipine and Bosentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms when bosentan is started or stopped. Adjust the amlodipine dose if needed.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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