Drug interactions
Amlodipine + Calcium
Severity: Minor
Amlodipine and Calcium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium given intravenously may reduce the blood pressure-lowering effect of calcium channel blockers like amlodipine. Oral calcium supplements at usual doses rarely have a meaningful effect.
What this interaction means in plain words
Amlodipine and Calcium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Calcium belongs to Gastrointestinal Tract.
Why it happens
Elevated extracellular calcium functionally opposes calcium channel blockade.
What to do
No routine action is needed with oral calcium. Monitor blood pressure when giving IV calcium to patients on amlodipine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Calcium?
MediHelp rates the interaction as minor. Amlodipine and Calcium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium given intravenously may reduce the blood pressure-lowering effect of calcium channel blockers like amlodipine. Oral calcium supplements at usual doses rarely have a meaningful effect.
How serious is the interaction between Amlodipine and Calcium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed with oral calcium. Monitor blood pressure when giving IV calcium to patients on amlodipine.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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