Drug interactions
Amlodipine + Carbidopa
Severity: Moderate
Amlodipine and Carbidopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa is given with levodopa, and levodopa-carbidopa can cause orthostatic hypotension. Combined with amlodipine, blood pressure lowering may be additive, especially when dopaminergic therapy is started or increased. Carbidopa alone has little hemodynamic effect.
What this interaction means in plain words
Amlodipine and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine belongs to Cardiovascular; Carbidopa belongs to Central Nervous System.
Why it happens
Additive hypotensive effects of levodopa-related dopaminergic therapy and calcium channel blocker vasodilation.
What to do
Check blood pressure, including standing readings, when levodopa-carbidopa is started or titrated in patients on amlodipine. Reduce the amlodipine dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Other interactions of Carbidopa
Frequently asked questions
Can I take Amlodipine with Carbidopa?
MediHelp rates the interaction as moderate. Amlodipine and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa is given with levodopa, and levodopa-carbidopa can cause orthostatic hypotension. Combined with amlodipine, blood pressure lowering may be additive, especially when dopaminergic therapy is started or increased. Carbidopa alone has little hemodynamic effect.
How serious is the interaction between Amlodipine and Carbidopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure, including standing readings, when levodopa-carbidopa is started or titrated in patients on amlodipine. Reduce the amlodipine dose if symptomatic hypotension occurs.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Activated Charcoal. The full list is on the Amlodipine page.
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