Drug interactions
Amlodipine + Chloramphenicol
Severity: Minor
Amlodipine and Chloramphenicol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may raise amlodipine levels by inhibiting its metabolism, potentially causing hypotension, edema or reflex tachycardia. The effect is probably modest and is mainly relevant in older or frail patients.
What this interaction means in plain words
Amlodipine and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine belongs to Cardiovascular; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Chloramphenicol inhibits CYP3A4, reducing amlodipine clearance.
What to do
Monitor blood pressure and for peripheral edema during chloramphenicol therapy. Adjust the amlodipine dose if hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloramphenicol
Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
Frequently asked questions
Can I take Amlodipine with Chloramphenicol?
MediHelp rates the interaction as minor. Amlodipine and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol may raise amlodipine levels by inhibiting its metabolism, potentially causing hypotension, edema or reflex tachycardia. The effect is probably modest and is mainly relevant in older or frail patients.
How serious is the interaction between Amlodipine and Chloramphenicol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for peripheral edema during chloramphenicol therapy. Adjust the amlodipine dose if hypotension develops.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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